Cu(II)-Catalyzed Benzannulation of Triynols to Synthesize β-Naphthyl Ketones Using Methanol as a Traceless Protective Agent
Abstract
Herein, we report an efficient copper(II)/oxamide-catalyzed cascade reaction of triynols. The reaction process appears to involve a Cu(II)-catalyzed tandem nucleophilic substitution reaction of the methanol/interrupted Meyer-Schuster rearrangement/aromatic annulation reaction. This approach provides a simple and efficient route to obtaining a wide variety of highly functionalized aromatic ketones under mild reaction conditions. Based on control experiments and deuterium labeling experiments, a catalytic mechanism was proposed.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Alkyne Reactions
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 7
- Pages
- 3025–3030
- Publication date
- 5 February 2026
- Language
- EN