Selective Construction of Xanthate-Functionalized Allylic Sulfonyl Fluorides via a Three-Component Process

The Journal of Organic Chemistry 2026

View at publisher
Authors: Monday Peter Ajisafe, Idrees Idrees Aliyu, Bright Bassey Oyom, Eman Mohammed Fayad, Dalal Nasser Binjawhar, Hua‐Li Qin
DOI: 10.1021/acs.joc.5c03022
Cited by: 2
References: 50

Abstract

A one-pot protocol for the addition of naturally rich alcohols, carbon disulfide and 2-chloroprop-2-ene-1-sulfonyl fluoride (CESF) for the selective synthesis of a class of novel xanthate-functionalized allylic sulfonyl fluorides has been developed, affording isolated yields up to 99%. Subsequent SuFEx transformations and the modification of natural and pharmaceutical compounds were achieved with remarkable efficiency, offering promising applications in biological and medicinal chemistry.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Fluorine in Organic Chemistry Click Chemistry and Applications

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
6
Pages
2641–2648
Publication date
3 February 2026
Language
EN