Visible Light-Induced Cyclization of N -Arylmethacrylohydrazides and Hydroxamic Acid Derivatives toward δ-Amidoalkylated Pyrazol-5-ones via 1,5-Hydrogen Atom Transfer
Abstract
-arylmethacrylohydrazides and hydroxamic acid derivatives for the synthesis of pyrazol-5-ones via 1,5-hydrogen atom transfer was developed. A series of pyrazol-5-ones was obtained in good yield with a broad substrate scope and excellent functional group compatibility. The procedure was also applied to the late-stage modification of natural products and drug molecules.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 4
- Pages
- 1805–1816
- Publication date
- 21 January 2026
- Language
- EN