Amines as Dual C2 Surrogates: I 2 /DTBP-Mediated Synthesis of Quinolines from Aniline Derivatives
Abstract
/DTBP-promoted synthesis of quinoline derivatives from arylamines and tertiary alkylamines is described. The reaction proceeds with tertiary alkylamines serving as dual C2 surrogates to forge C-N and C-C bonds under operationally simple conditions. The reaction accommodates a range of alkylamines as alkyl donors and tolerates diverse functional groups, delivering quinoline frameworks. Notably, the 2-methylquinoline derivatives feature a reactive benzylic methyl group, serving as a versatile handle for downstream functionalization.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Synthesis and Reactivity of Heterocycles
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 8
- Pages
- 3273–3278
- Publication date
- 16 February 2026
- Language
- EN