Base-Promoted S -Alkylation of Sulfenamides with Cyclic Sulfonium Salts
Abstract
S -alkylation of sulfenamides is a promising strategy to access sulfilimine compounds that play important roles in chemical biology and synthetic chemistry. Herein, we report a base-promoted S -alkylation of sulfenamides with cyclic sulfonium salts as alkylating reagents, which delivered the sulfilimines featuring alkenyl/alkynyl thioether moieties. This practical method shows the advantages of mild conditions, operational simplicity, and broad substrate scope. Moreover, the synthetic potential of this method was demonstrated by a one-pot synthesis and late-stage diversification of drug-relevant molecules.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Synthesis and Catalytic Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 10
- Pages
- 3906–3912
- Publication date
- 26 February 2026
- Language
- EN