NHC·CS 2 (NHC = N -Heterocyclic Carbene) Species as Reductive Mediators in the Electrosynthesis of Coumarins
Abstract
Coumarins represent an important class of heterocycles because of their prevalence in nature and their common presence as pharmaceutical structural motifs. However, their synthesis employs harsh conditions or requires a transition metal catalyst, limiting their scalability and sustainability. Herein we report an electrocatalytic synthetic method leading to coumarins using NHC·CS 2 (NHC = N-heterocyclic carbene) species as organic mediators. Using this procedure, a variety of substituted coumarins were obtained in good yields, establishing this electrocatalytic strategy as an attractive synthetic alternative. Based on our observations, a reaction mechanism operating through a one-electron reduction and involving a radical intermediate is proposed.
Fields of Study & Subjects
N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Radical Photochemical Reactions
Ammonia Synthesis and Nitrogen Reduction
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 10
- Pages
- 3732–3743
- Publication date
- 4 March 2026
- Language
- EN