Decarboxylative (Thio)esterification of α-Keto Acids via Carbonyl-Photoredox/Copper Dual Catalysis

The Journal of Organic Chemistry 2026

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Authors: Da‐Liang Zhu, Jie Li, David James Young, Yanqing Wang, Chang Cheng, Hong‐Xi Li
DOI: 10.1021/acs.joc.5c03066
Cited by: 0
References: 78

Abstract

An efficient visible-light-induced copper-catalyzed decarboxylative (thio)esterification of α-keto acids with (thio)phenols has been developed using 2-chloro-thioxanthen-9-one as the photocatalyst and dimethyl sulfoxide (DMSO) as the terminal oxidant and solvent, enabling the efficient synthesis of aryl (thio)benzoates in moderate to excellent yields (66 examples). This operationally simple protocol exhibits excellent tolerance toward various functional groups, has been applied to the synthesis of pharmaceutical/natural product derivatives, and proceeds efficiently on a gram scale.

Fields of Study & Subjects

Radical Photochemical Reactions Sulfur-Based Synthesis Techniques Chemical Synthesis and Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Volume
91
Issue
6
Pages
2606–2619
Publication date
30 January 2026
Language
EN