Electrochemical Phosphorochalcogenations for the Synthesis of Phosphorochalcogenothioates
Abstract
High Resolution Image Download MS PowerPoint Slide We report a robust and environmentally conscious electrosynthetic protocol for the efficient construction of structurally diverse and biologically relevant phosphorochalcogenated compounds. This transformation proceeds through the electrochemical cross-coupling of phosphonothioates with the corresponding thiols or diaryl diselenides using inexpensive NaI or n Bu 4 NI as both a green electrolyte and redox mediator. The reactions are carried out in CH 3 CN at room temperature under a constant current of 10 mA with Pt/Pt electrodes. This newly developed method offers several notable advantages, including mild and energy-efficient conditions, transition-metal-free operation, short reaction times, moderate to high yields, broad substrate scope, large-scale applicability, operational simplicity, and overall environmental sustainability.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Radical Photochemical Reactions
Phosphorus compounds and reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 14
- Pages
- 4962–4975
- Publication date
- 25 March 2026
- Language
- EN