Sulfonium Salt-Mediated Dithiocarbamation of Terminal Alkynes with CS 2 and Amines for Access to Z -Bis(dialkylaminethiocarbonyl) Alkenes
Abstract
In this work, we report a practical and convenient one-pot, two-step synthesis of diverse bis(dialkylaminothiocarbonyl) alkenes mediated by alkynyl sulfonium salt intermediates. This strategy enables facile access to alkenylated dithiocarbamates in moderate to good yields with exclusive Z-selectivity. The synthetic utility of this protocol is further demonstrated by its successful application in a scale-up reaction and late-stage functionalization, rendering it attractive for organic synthesis.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Synthesis and Reactivity of Sulfur-Containing Compounds
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 23
- Pages
- 7640–7646
- Publication date
- 27 May 2026
- Language
- EN