Cascade Photofragmentation/Photoalkylation for the Synthesis of α-Tertiary Alkyl Primary Amines
Abstract
N -H imines are synthetically versatile but sensitive intermediates in organic synthesis. This work introduces a cascade synthesis of basic amines through N -H imine intermediates, featuring an efficient aza -Norrish Type II fragmentation, followed by photoalkylation. Our method selectively converts bench-stable phenacylamines to α-quaternary primary amines in one pot using mild and metal-free UV photocatalysis. Our work constitutes a rare use of amine photofragmentation in organic synthesis.
Fields of Study & Subjects
Radical Photochemical Reactions
Chemical Reactions and Mechanisms
Synthesis and Catalytic Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 5
- Pages
- 2315–2319
- Publication date
- 27 January 2026
- Language
- EN