Rhodium(II/III)-Catalyzed P(III)-Directed ortho C–H Diarylation/Monoalkylation of 7-Aryl-pyrrolo[2,3- d ]pyrimidine Derivatives
Abstract
Rh-catalyzed, P(III)-directed arene ortho C-H diarylation and monoalkylation reactions of 7-aryl-pyrrolo[2,3- d ]pyrimidine derivatives have been developed. A series of structurally diverse diarylated and monoalkylated phosphoryl-substituted pyrrolo[2,3- d ]pyrimidine derivatives were obtained in moderate to good yields. The broad substrate scopes, good functional group tolerance, and high site selectivity render this strategy well-suited for the late-stage structural modification of pyrrolo[2,3- d ]pyrimidine-based natural products and pharmaceuticals. This protocol enriches the library of biologically privileged pyrrolo[2,3- d ]pyrimidine derivatives for further pharmacological evaluation.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Cyclopropane Reaction Mechanisms
Fluorine in Organic Chemistry
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 23
- Pages
- 7653–7667
- Publication date
- 3 June 2026
- Language
- EN