Diversity-Oriented Synthesis of CF 3 -Functionalized Polycyclic Spiroisoxazolones via Organobase-Promoted Vinylogous Michael Addition Cascade Reactions

The Journal of Organic Chemistry 2026

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Authors: Ganesh Shantaram Khomane, Chengcai Liu, Chia-Yen Chang, Wei-Chi Wu, Yadav Kacharu Nagare, Tzu-Chun Yen, Wenwei Lin
DOI: 10.1021/acs.joc.6c00026
Cited by: 1
References: 52

Abstract

-tethered enediones. Additionally, the asymmetric variant of the spiro-fused isoxazolone scaffolds was also achieved using a bifunctional squaramide catalyst. Control experiments confirmed the reversibility and stability of the hemiketal and ketal groups in spiroisoxazolones. Gram-scale synthesis and derivatization further demonstrated the synthetic utility.

Fields of Study & Subjects

Fluorine in Organic Chemistry Synthesis and Reactions of Organic Compounds Sulfur-Based Synthesis Techniques

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
16
Pages
5705–5712
Publication date
13 April 2026
Language
EN