Palladium Catalyzed Asymmetric C(sp)–P Cross-Coupling via Kinetic Resolution of Secondary Phosphine Oxides

The Journal of Organic Chemistry 2026

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Authors: Jianguo Gu, Yuen Wu, Tang Zhongkuan, S. H. Liu, Bo Yu, Jingwen Luo, Bindong Li, Dinghai Wang
DOI: 10.1021/acs.joc.6c00057
Cited by: 2
References: 40

Abstract

Herein, we report a palladium-catalyzed asymmetric C(sp)–P cross-coupling reaction between secondary phosphine oxides (SPOs) and alkynyl chlorides, providing a direct and efficient route to access P-stereogenic alkynyl phosphine oxides via a kinetic resolution process. This method proceeds under mild conditions, delivering products with excellent enantioselectivity (up to 94% ee ) and good functional group tolerance. This work offers a straightforward and modular strategy for the synthesis of valuable chiral alkynyl phosphorus compounds.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Asymmetric Hydrogenation and Catalysis Catalytic C–H Functionalization Methods

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
13
Pages
4776–4786
Publication date
20 March 2026
Language
EN