CuI-Catalyzed Trifluoromethylation/Cyclization Reaction of N -(2-Methylallyl)-2-arylindoles: Access to Trifluoromethylated Indolo[2,1- a ]isoquinoline (Benzo[4,5]imidazo[2,1- a ]isoquinoline) Derivatives

The Journal of Organic Chemistry 2026

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Authors: Mengyan Ning, Tongqin Cai, Mei Pan, Jingyao Su-Zhang, Jing Yang, Xiaoqin Liu, Liangce Rong
DOI: 10.1021/acs.joc.6c00080
Cited by: 2
References: 61

Abstract

The copper(I)-catalyzed radical cascade trifluoromethylation/cyclization reaction of N -allyl-2-arylindoles and Togni reagent (II) was developed to achieve diverse CF 3 -substituted indolo[2,1- a ]isoquinoline (benzo[4,5]imidazo[2,1- a ]isoquinoline) derivatives in this synthesis. The main features of this strategy include a wide substrate scope, good functional group tolerance, and moderate to good yields, which provide a valuable strategy for the synthesis of trifluoromethylated indolo[2,1- a ]isoquinoline (benzo[4,5]imidazo[2,1- a ]isoquinoline) derivatives.

Fields of Study & Subjects

Fluorine in Organic Chemistry Catalytic C–H Functionalization Methods Synthesis and Characterization of Pyrroles

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
10
Pages
3894–3899
Publication date
25 February 2026
Language
EN