Iron-Catalyzed Site-Selective γ-C(sp 3 )-H Azidation of Hydroxylamine Derivatives
Abstract
)-H azidation that proceeds with exclusive γ-selectivity relative to the carbonyl group via a 1,5-hydrogen atom transfer process initiated by an iron-nitrenoid species. This strategy, based on the combination of hydroxylamine derivatives and trimethylsilyl azide with a simple iron catalyst, provides efficient access to a broad range of azido-amide and azido-carbamate products.
Fields of Study & Subjects
Synthesis and Catalytic Reactions
Catalytic C–H Functionalization Methods
Click Chemistry and Applications
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 14
- Pages
- 5127–5137
- Publication date
- 27 March 2026
- Language
- EN