Cu/Zn-Catalyzed Synthesis of ε-Keto Sulfones from Cyclopropanols

The Journal of Organic Chemistry 2026

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Authors: Zhixin Deng, Zhigang Liu, Sheng Zuo, Ya-Jiao Zhang, Hong Yan, Fen-Er Chen
DOI: 10.1021/acs.joc.6c00088
Cited by: 1
References: 69

Abstract

ε-Keto sulfones, which are useful building blocks in organic chemistry and drug discovery, motivated us to develop a new protocol for their synthesis from cyclopropanols via Cu/Zn-cocatalyzed ring-opening conjugate addition to vinyl sulfones. cis -2-Amino-1,2-diphenyl-ethanol is disclosed as an effective ligand to promote this transformation. Moreover, other Michael acceptors, including benzylidene malononitrile, maleimide, and α,β-unsaturated ketones or esters, are also compatible with the protocol.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Cyclopropane Reaction Mechanisms Catalytic C–H Functionalization Methods

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
14
Pages
5115–5126
Publication date
29 March 2026
Language
EN