Access to α-Pyrones via an NHC-Catalyzed Formal [3 + 3] Cycloaddition/Elimination

The Journal of Organic Chemistry 2026

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Authors: Minjie Bi, Feiyang Li, Minni Qi, Yihui Zhang, Yinyin Wu, Kai Ding, Guofu Zhong, Limin Yang
DOI: 10.1021/acs.joc.6c00163
Cited by: 1
References: 65

Abstract

α-Pyrones, which serve as core structures in many natural products and important biomolecules, exhibit promising biological activities. Herein, we report an efficient N-heterocyclic carbene (NHC)-catalyzed formal [3 + 3] cycloaddition/elimination reaction that directly converts readily available α-bromocinnamaldehydes and pyridinium salts into diverse α-pyrones under mild conditions. This method exhibits broad functional group tolerance and delivers a wide range of substituted α-pyrone derivatives in high yields.

Fields of Study & Subjects

N-Heterocyclic Carbenes in Organic and Inorganic Chemistry Cyclopropane Reaction Mechanisms Catalytic Alkyne Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
15
Pages
5439–5446
Publication date
4 April 2026
Language
EN