Visible-Light-Mediated Multicomponent Synthesis of Azido-Substituted gem -Difluoroalkenes

The Journal of Organic Chemistry 2026

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Authors: Jiabin Shen, Du Hu, Ye Chen, Hao Xu, Donghao Wang, Kai Ge, Chao Shen, Min Wang
DOI: 10.1021/acs.joc.6c00207
Cited by: 8
References: 55

Abstract

Herein, a photocatalytic strategy for the synthesis of gem -difluoroalkenes by the multicomponent cascade reaction of α-trifluoromethyl alkenes with alkenes and TMSN 3 is described. This operationally simple protocol provides a powerful strategy to introduce azido fragments into gem -difluoroalkenes, enriching the current library of gem -difluoroalkenes for drug discovery. A gram-scale synthesis and synthetic applications demonstrate the potential application of this methodology in the synthesis of diverse medicinally relevant compounds.

Fields of Study & Subjects

Fluorine in Organic Chemistry Click Chemistry and Applications Radical Photochemical Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
14
Pages
5201–5207
Publication date
30 March 2026
Language
EN