Asperiecolins A–D: Undescribed Variecolin-Type Sesterterpenoids with Anti-Inflammatory and AChE Inhibitory Activities from Aspergillus sp. TJ403-YJ22

The Journal of Organic Chemistry 2026

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Authors: Jun Yao, Jiangchun Wei, Xingpiao Jin, Yan He, Ning Wang, Yi-Xiang Wang, Yonghui Zhang, Zhengxi Hu
DOI: 10.1021/acs.joc.6c00291
Cited by: 1
References: 34

Abstract

Four new sesterterpenoids, designated as asperiecolins A–D ( 1 – 4 ), were isolated from fungus Aspergillus sp. TJ403-YJ22. Asperiecolin A ( 1 ) possesses an unprecedented 5/8/6/6/5-fused pentacyclic framework with 11 stereocenters, while asperiecolins B ( 2 ) and C ( 3 ) feature an unusual five-membered lactam ring. All compounds inhibited LPS-induced NO and TNF-α production in macrophages. Additionally, compound 1 exhibited potent AChE inhibition (IC 50 = 0.67 ± 0.05 μM), highlighting its therapeutic potential for inflammatory and neurodegenerative diseases.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Fungal Biology and Applications Fungal and yeast genetics research

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
16
Pages
5723–5729
Publication date
15 April 2026
Language
EN