Visible-Light-Promoted Radical Acylation/Cyclization of Bicyclobutyl N -Aryl Amides with 4-Acyl-1,4-Dihydropyridines

The Journal of Organic Chemistry 2026

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Authors: Jian-Hong Fan, Peng-Fei Xia, Jiao Zhou, Chang-Deng Liu, Quan Zhou, Yu Liu
DOI: 10.1021/acs.joc.6c00297
Cited by: 1
References: 54

Abstract

We report a radical cascade acylation/cyclization of bicyclobutyl N -aryl amides with 4-acyl-1,4-dihydropyridines under visible-light irradiation. This transformation tolerates a broad range of functional groups and offers an alternative, environmentally benign approach to the synthesis of acyl-containing spirocyclic oxindoles.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
24
Pages
8151–8162
Publication date
4 June 2026
Language
EN