Modular and Practical Synthesis of Primary Benzyl Boronic Esters from Aryl Iodides via One-Carbon Homologation
Abstract
Herein, we report a one-carbon homologation strategy for the synthesis of primary benzyl boronic acid pinacol esters from aryl iodides and a chloromethyl boron reagent. This method provides efficient access to a broad range of benzyl boronic esters with clean reaction profiles, accommodates diverse functional groups and heterocycles, and enables gram-scale synthesis as well as versatile downstream transformations.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Organoboron and organosilicon chemistry
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 12
- Pages
- 4521–4527
- Publication date
- 16 March 2026
- Language
- EN