Tungsten-Mediated Decarboxylative C(sp 3 )–O Bond Formation through Ligand-to-Metal Charge Transfer

The Journal of Organic Chemistry 2026

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Authors: Siyu He, P. Bai, Yi Huang, Chen Xu, Shu-Fen Hou, Heng Song
DOI: 10.1021/acs.joc.6c00328
Cited by: 1
References: 51

Abstract

)-O bond formation reaction under mild, base-free conditions with irradiation. This transformation employs readily available carboxylic acids as substrates and 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) as oxygenation reagent. The protocol exhibits a broad substrate scope and has been successfully applied to the late-stage functionalization of bioactive molecules.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
17
Pages
6024–6034
Publication date
17 April 2026
Language
EN