Rhodium(III)-Catalyzed C–H Bond Activation and [3+3] Spirocyclization of Benzoxazines with CF 3 -Imidoyl Sulfoxonium Ylides toward Trifluoromethyl-Substituted Spiroheterocyclic Compounds
Abstract
-imidoyl sulfoxonium ylides (TFISYs) have been achieved, providing a direct and facile avenue to structurally diverse trifluoromethyl-substituted spiroheterocycles. The transformation involves a cascade C-H activation, tautomerization, and intramolecular nucleophilic addition pathway. A broad spectrum of spiroheterocycle molecules containing biologically important benzoxazine and isoquinoline skeletons are synthesized in up to 98% yields.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Fluorine in Organic Chemistry
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 15
- Pages
- 5388–5401
- Publication date
- 3 April 2026
- Language
- EN