Tandem WGSR-Inspired Nitroarene Reductive Carbonylative C–N Coupling for Nongaseous Amide Synthesis

The Journal of Organic Chemistry 2026

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Authors: Hongyu Yang, Jinghui Yang, Yi-Xiang Wang, Wenzhe Wang, Wenzhe Wang, Weiqiang Zhang, Jianming Yang, Jianming Yang, Ziwei Gao
DOI: 10.1021/acs.joc.6c00349
Cited by: 1
References: 53

Abstract

A tandem reductive carbonylation of nitroarenes with boronic acids is achieved under mild conditions (65 °C, ambient pressure), using Fe(CO) 5 and H 2 O as a bifunctional syngas surrogate. The Fe(CO) 5 -mediated water–gas shift reaction (WGSR) generates hydrides for nitro reduction and supplies CO in situ for Pd-catalyzed carbonylative C–N coupling. This operationally simple protocol provides direct access to amides without external CO/H 2, exhibiting broad functional group tolerance and an enhanced safety profile.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Asymmetric Hydrogenation and Catalysis Catalytic C–H Functionalization Methods

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
20
Pages
6919–6928
Publication date
6 May 2026
Language
EN