Ir-Catalyzed Asymmetric Allylic Substitution of Hydrazine Derivatives
Abstract
For the synthesis of chiral hydrazine-containing intermediate 2a, enantioselective allylic substitution using N -aminophthalimide was evaluated. A method was developed that enabled the desired transformation to be performed in an enantioselective and regioselective manner. The substrate scope with respect to hydrazine derivatives and different allylic carbonates was evaluated. A telescoped sequence for phthalimide deprotection and pyrazole synthesis without the need to isolate the deprotected hydrazine intermediate was also demonstrated.
Fields of Study & Subjects
Asymmetric Synthesis and Catalysis
Asymmetric Hydrogenation and Catalysis
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 22
- Pages
- 7579–7584
- Publication date
- 21 May 2026
- Language
- EN