Synthesis of 3-Difluoromethyl-1,3,4-oxadiazole-thiones from Aroylhydrazides, TMSCF 3 , and Elemental Sulfur

The Journal of Organic Chemistry 2026

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Authors: Xi Zhang, Jiahe Zou, Jiawei Dong, Xia Gao, Dong Lu, Renhua Qiu, Jinyao Li
DOI: 10.1021/acs.joc.6c00453
Cited by: 1
References: 36

Abstract

as a difluoromethylation reagent and nontoxic elemental sulfur as a sulfurizing agent. Preliminary bioactivity evaluation indicated that most of the synthesized compounds possess certain potential anticancer activity.

Fields of Study & Subjects

Structural and Chemical Analysis of Organic and Inorganic Compounds Fluorine in Organic Chemistry Synthesis and Reactivity of Sulfur-Containing Compounds

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
24
Pages
8191–8205
Publication date
6 June 2026
Language
EN