Light-Induced Site-Selective Functionalization of Tertiary C(sp 3 )–H Bonds via a Synergistic System Combining TBADT with a Thiol Catalyst

The Journal of Organic Chemistry 2026

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Authors: Wenbin Xu, Jiajun Wang, Liying Yu
DOI: 10.1021/acs.joc.6c00460
Cited by: 1
References: 102

Abstract

A site-selective functionalization of C(sp 3 )–H bonds is described. Electrophilic alkenes and alkynes are used to perform the site-selective functionalization of tertiary C(sp 3 )–H bonds enabled by merging a tetrabutylammonium decatungstate (TBADT) as a hydrogen atom abstractor (HAA) and a thiol as a hydrogen atom donator (HAD) under light irradiation. Excess use of substrates could be avoided; greater than 20:1 site selectivity and up to 84% yield could be obtained with the help of 2,4,6-tri- tert -butylbenzenethiol.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Sulfur-Based Synthesis Techniques

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
20
Pages
7100–7109
Publication date
7 May 2026
Language
EN