HFIP-Promoted One-Pot Synthesis of Indolines and Pyrrolidines
Abstract
-heterocycles from readily available amines and alkyl halides in HFIP has been developed. HFIP enables sequential alkylation and cyclization in a one-pot process under acidic conditions. A range of indoline and pyrrolidine derivatives were obtained in moderate to good yields with tolerance toward various functional groups and nitrogen substitution patterns. The synthetic utility of this approach was demonstrated through gram-scale reactions, further transformations of pyrrolidines, and a concise formal synthesis of cephalotaxine.
Fields of Study & Subjects
Biological Activity of Diterpenoids and Biflavonoids
Synthesis and bioactivity of alkaloids
Synthesis of Organic Compounds
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 22
- Pages
- 7513–7518
- Publication date
- 20 May 2026
- Language
- EN