Palladium-Catalyzed [4 + 2] Cycloaddition of Isatin-Derived Hydroxy-Tethered Allylic Carbonates with Alkenes

The Journal of Organic Chemistry 2026

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Authors: Shuang Gu, Yue Wang, Mengxi Lu, Honghao Sun, J Liu, L J Zhou, Bing Zheng, Hongchao Guo
DOI: 10.1021/acs.joc.6c00694
Cited by: 1
References: 53

Abstract

A palladium-catalyzed [4 + 2] cycloaddition of isatin-derived hydroxy-tethered allylic carbonates with 1,1-dicyanoalkenes has been developed to afford various spirooxindole-tetrahydropyran derivatives in moderate to high yields with excellent diastereoselectivities. The scale-up reaction and further derivations of the product also worked well. The current reaction demonstrated that isatin-derived hydroxy-tethered allylic carbonates are viable precursors for palladium-catalyzed cycloaddition reactions and are expected to find broader applications.

Fields of Study & Subjects

Carbon dioxide utilization in catalysis Catalytic C–H Functionalization Methods Cyclopropane Reaction Mechanisms

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
21
Pages
7311–7321
Publication date
15 May 2026
Language
EN