Stereodefined Synthesis of Acyclic meso -2,3-Diaryl Dialdehydes and Their Iridium-Catalyzed Enantioselective Desymmetrization

The Journal of Organic Chemistry 2026

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Authors: Runze Zhao, Da‐Yang Zhou, Kaori Asano, Takayoshi Suzuki, Takeyuki Suzuki, Takeyuki Suzuki, Takeyuki Suzuki
DOI: 10.1021/acs.joc.6c00927
Cited by: 1
References: 13

Abstract

Efficient enantioselective desymmetrization of acyclic meso-dialdehydes has remained unexplored due to limited substrate access. We report a stereodefined synthesis of acyclic meso-2,3-diaryl dialdehydes and their iridium-catalyzed enantioselective desymmetrization to give γ-butyrolactones in up to 96% ee. Hydrogen-donor-free conditions enable in situ Ir-hydride generation for certain substrates. This method enables catalytic asymmetric access to cinncassin A1.

Fields of Study & Subjects

Asymmetric Hydrogenation and Catalysis Organometallic Complex Synthesis and Catalysis Asymmetric Synthesis and Catalysis

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
30
Pages
10461–10465
Publication date
26 June 2026
Language
EN