Photocatalytic Decarboxylative Coupling of Diacyl Peroxides with TEMPO
Abstract
The facile construction of C(sp 3 )-O bonds plays a critically important role in organic synthesis. Herein, we report a visible-light-mediated decarboxylative C(sp 3 )-O bond formation reaction under metal- and base- and additive-free conditions with irradiation. This protocol is characterized by its broad substrate compatibility and operational simplicity. Meanwhile, the potential applications of this operationally simple and general methodology in synthetic chemistry have been demonstrated by the late-stage functionalization of bioactive molecules and subsequent modifications of TEMPO derivatives.
Fields of Study & Subjects
Radical Photochemical Reactions
Oxidative Organic Chemistry Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 28
- Pages
- 9895–9899
- Publication date
- 7 July 2026
- Language
- EN