Copper-Catalyzed C–H Sulfonylation with NSAPI Participation under the Assistance of Directing Group
Abstract
Herein, we describe an efficient ortho C-H sulfonylation of 8-aminoquinoline-tethered benzoic acid derivatives using N-sulfonyl-aminophthalimide (NSAPI) as the sulfonylating source. Mechanistic investigations support a radical process, wherein cleavage of the ortho C(sp2)-H bond is rate-determining. The active copper species is regenerated by atmospheric oxygen, allowing for low catalyst loading and broad substrate/functional group tolerance.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 32
- Pages
- 11148–11155
- Publication date
- 4 August 2026
- Language
- EN