Novel and Cost-Effective Method for Synthesizing Blarcamesine Hydrochloride Using Quality by Design Principles

Organic Process Research & Development 2026

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Authors: Shravan Kumar Komati, Santhosh Kumar Kodide, Adi Reddy Dwarampudi, Amarendhar Manda, Mukesh Kumar Madhra, L. Busi Reddy, Srinivas Maram, Yamparala Rakesh, Sasikala Cheemalapati Venkata Annapurna, Gopal Chandru Senadi, Arthanareeswari Maruthapillai, Rakeshwar Bandichhor
DOI: 10.1021/acs.oprd.5c00361
Cited by: 0
References: 12

Abstract

Blarcamesine hydrochloride is an experimental drug currently in development for treating Alzheimer’s disease and other conditions. The innovator, Anavex Life Sciences Corporation, reported the synthesis of blarcamesine hydrochloride but faced challenges such as low yields and issues with large-scale production, which significantly increased the cost of the drug substance. This report outlines a cost-effective and innovative process for synthesizing blarcamesine hydrochloride amenable to commercial manufacturing. Additionally, we improved the process efficiency by increasing overall throughput.

Fields of Study & Subjects

Innovative Microfluidic and Catalytic Techniques Innovation Chemical Synthesis and Analysis Pharmaceutical Quality and Counterfeiting

Publication details

Journal / source
Organic Process Research & Development
Volume
30
Issue
2
Pages
353–362
Publication date
9 January 2026
Language
EN