Scalable Continuous Flow Hydrogenation of Isoquinoline in Trickle-Bed Reactors

Organic Process Research & Development 2026

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Authors: WooSun Lee, Namyong Kim, Sangsun Joung, Beomjoo Maeng, Eunchae Song, Sangsun Park
DOI: 10.1021/acs.oprd.5c00411
Cited by: 0
References: 30

Abstract

A robust and scalable continuous-flow hydrogenation process was developed for the synthesis of 1,2,3,4-tetrahydroisoquinoline (THIQ) scaffold using a commercially available heterogeneous Pt/Al 2 O 3 catalyst in a trickle-bed reactor. This study outlines the systematic selection of catalysts and solvents as well as process optimization using the Design of Experiments (DoE). A scale-up run was successfully demonstrated at a 13 kg scale of THIQ with a 99% isolated yield in pilot equipment. This work demonstrates a practical strategy for the continuous-flow synthesis of THIQ, highlighting its potential for industrial.

Fields of Study & Subjects

Innovative Microfluidic and Catalytic Techniques Innovation Synthesis and Biological Activity Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Process Research & Development
Volume
30
Issue
2
Pages
431–439
Publication date
9 February 2026
Language
EN