Advancing Process Chemistry through HTE Kinetics: Development and Implementation of Innovative Workflows

Organic Process Research & Development 2026

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Authors: Toby H. Waldron Clarke, Cristina García‐Morales, Annabel J. Morris, Robert J. Cox, Larry Hoteite, Brian A. Taylor, Ian D. G. Nixon, Andy Yen
DOI: 10.1021/acs.oprd.5c00514
Cited by: 1
References: 32

Abstract

Data-rich synthetic chemistry, enabled by high-throughput experimentation (HTE) and automation, allows the acquisition of concentration data across the full time-course of multiparallel reactions. This approach is both time- and material-efficient and can be leveraged for strategies beneficial to pharmaceutical process development, including reaction profiling, visual kinetic analysis, and predictive kinetic and hybrid reaction modeling. Here, we describe the development and adoption of HTE kinetics workflows within AstraZeneca’s process chemistry department and the advantages realized.

Fields of Study & Subjects

Chemistry and Chemical Engineering Innovative Microfluidic and Catalytic Techniques Innovation Various Chemistry Research Topics

Publication details

Journal / source
Organic Process Research & Development
Publisher
American Chemical Society (ACS)
Volume
30
Issue
3
Pages
779–794
Publication date
4 March 2026
Language
EN