NNO-Ru Complexes Catalyzed Selective Synthesis of Bisindolylmethanes via Interrupted Borrowing Hydrogen Strategy
Abstract
Herein, three NNO-Ru complexes were synthesized and demonstrated to be efficient catalysts for the selective alkylation of indoles with various alcohols via the interrupted borrowing hydrogen (IBH) strategy. A diverse array of bisindolylmethane derivatives, including several structurally important compounds such as Turbomycin B, Arundone, and anticancer agents were achieved in good to excellent yields. The reactions were conducted in an atom- and step-economical manner under mild conditions, accommodating both primary and secondary alcohols.
Fields of Study & Subjects
Synthesis of Indole Derivatives
Asymmetric Hydrogenation and Catalysis
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Organometallics
- Publisher
- American Chemical Society (ACS)
- Volume
- 45
- Issue
- 4
- Pages
- 483–493
- Publication date
- 10 February 2026
- Language
- EN