Direct Stereoselective Synthesis of a Single (ebthi)Ti(BINOLate) Catalyst Enantiomer
Abstract
High Resolution Image Download MS PowerPoint Slide Despite their prominence as privileged chiral catalysts for synthesis and polymer chemistry, the synthesis of enantiopure ebthi-type titanocenes is a challenging task. In this proof-of-concept study, we report the development of a single-step synthesis of ( S, S, S )-(ebthi)Ti(BINOLate) from Li 2 (ebthi) and ( S )-Ti(BINOLate)Cl 2 in 28% yield with 97% ee. We further shed light on the nature of the latter and provide alternative protocols for the convenient liberation of ( S )-(ebthi)TiCl 2 . (ebthi)-Ti(BINOLate) is further shown to be a competent catalyst in asymmetric ketone-nitrile couplings, providing an enantioselectivity comparable to that of (ebthi)TiCl 2 .
Fields of Study & Subjects
Asymmetric Synthesis and Catalysis
Asymmetric Hydrogenation and Catalysis
Organometallic Complex Synthesis and Catalysis
Publication details
- Journal / source
- Organometallics
- Volume
- 45
- Issue
- 5
- Pages
- 580–586
- Publication date
- 16 February 2026
- Language
- EN