Temperature Dependent Divergent Radical Oxidative Amidation Engaging Arylglyoxyl Radicals
Abstract
The present study reports the divergent reaction of previously underexplored arylglyoxyl radicals generated in situ from arylglyoxals in the presence of tert -butyl hydroperoxide (TBHP) and a catalytic amount of iodine with various amines at two different temperatures leading to the synthesis of arylglyoxal amides at 120 °C and aromatic amides at 180 °C. The two radicals, arylglyoxyl radical and aroyl radical, generated via decarbonylation at higher temperature, could react with amines via radical polar crossover.
Fields of Study & Subjects
Oxidative Organic Chemistry Reactions
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 4
- Pages
- 1147–1152
- Publication date
- 19 January 2026
- Language
- EN