Mechanochemistry-Enhanced Regioselective Hydrophosphinylation of Acrylamides and Enamides

Organic Letters 2026

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Authors: Zi-Kui Liu, Yun-Kun Su, Cong-Fang Cheng, Hao Dong, Yi Wei, Xiao‐Qiang Hu, You‐Quan Zou
DOI: 10.1021/acs.orglett.5c04617
Cited by: 1
References: 69

Abstract

Herein, we report a ball milling technique for the regioselective hydrophosphinylation of acrylamides and enamides, utilizing readily available Ph 2 PCl as the phosphine source and H 2 O as an additive under metal-free and toxic solvent-free conditions. Michael-type and Markovnikov hydrophosphinylation reactions have been achieved for acrylamides and enamides, respectively. The reaction features broad substrate scope, sustainable conditions and high atom economy, facilitating the rapid assembly of structurally diverse amide-based phosphine oxides in useful to good yields.

Fields of Study & Subjects

Organophosphorus compounds synthesis Asymmetric Hydrogenation and Catalysis Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
6
Pages
1929–1935
Publication date
30 January 2026
Language
EN