Electrochemical Radical Allylic Trifluoromethylation of Free Allylic Alcohols with Trifunctional Trifluoromethyl Thianthrenium Salts
Abstract
The radical allylic substitution of free allylic alcohols remains a challenge. Herein, we report an electrochemical strategy that facilitates the dehydroxylative allylic trifluoromethylation of unprotected allylic alcohols with thianthrenium salts, affording trisubstituted alkenes with high regio- and E / Z selectivities. The key to this success lies in the electrochemical unlocking of the unique trifunctionality of thianthrenium salts, which serve synergistically as radical precursors, sacrificial anodic agents, and deoxygenation mediators.
Fields of Study & Subjects
Radical Photochemical Reactions
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 2
- Pages
- 640–645
- Publication date
- 2 January 2026
- Language
- EN