Rhodium-Catalyzed [3 + 2] Annulation of 2-Benzylquinazolinones with Ketones for the Synthesis of Diversely Functionalized Pyrrolo[2,1- b ]quinazolinones

Organic Letters 2026

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Authors: Karuna Mahato, Divya Shrestha, Prasanta Roy, Rajeev Shrestha, Y. R. LEE
DOI: 10.1021/acs.orglett.5c04705
Cited by: 1
References: 70

Abstract

A Rh(III)-catalyzed [3 + 2] annulation strategy is developed for the synthesis of pyrrolo[2,1- b ]quinazolinones from readily available 2-benzylquinazolinones and ketones via sp 3 C–H activation. This protocol enables the efficient introduction of diverse functional groups such as aryl, polyaromatic, heteroaromatic, and alkyl substituents onto the bioactive pyrrolo[2,1- b ]quinazolinone frameworks depending on the ketone employed.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Quinazolinone synthesis and applications Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
2
Pages
651–657
Publication date
1 January 2026
Language
EN