Cationic Cascade Strategy for the Synthesis of Dihydrobenzofuran and Isochromane Scaffolds

Organic Letters 2026 Open access

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Authors: Patrycia K. Zybura, Kyla J. Grant, Alison J. Frontier
DOI: 10.1021/acs.orglett.5c04731
Cited by: 1
References: 29

Abstract

High Resolution Image Download MS PowerPoint Slide Oxygen heterocycles are valued for their prevalence in bioactive molecules and their metabolic stability. We report a Brønsted-acid-promoted, oxygen-interrupted halo -Prins/ halo -Nazarov cascade that enables the stereospecific construction of dihydrobenzofuran and isochromane scaffolds from simple enyne and carbonyl precursors. This approach unites de novo heterocycle construction with late-stage functionalization, providing access to complex oxygen heterocycles of relevance to medicinal chemistry.

Fields of Study & Subjects

Synthetic Organic Chemistry Methods Catalytic Alkyne Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
2
Pages
658–662
Publication date
6 January 2026
Language
EN