Aspersorbiciols A and B, Two Hybrid Sorbicillinoids with an Undescribed Skeleton from a Marine-Derived Fungus Aspergillus sp. GXIMD02072

Organic Letters 2026

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Authors: Quan Teng, Zhen Li, Pei Cao, Binghua Li, Chenghai Gao, Xuelian Qin, Yonghong Liu, Yanhui Tan, Xianqiang Chen
DOI: 10.1021/acs.orglett.5c04786
Cited by: 1
References: 36

Abstract

Aspersorbiciols A and B, two hybrid sorbicillinoids, were obtained from marine fungus Aspergillus sp. GXIMD02072. Their structures were elucidated by spectroscopic analyses, quantum chemical calculations, and X-ray diffraction. Structurally, aspersorbiciols A and B represented the first reported instances of sorbicillinoids incorporating a 2,6-dioxa-pentacyclo-[10.4.0.0 4,8 .0 4,16 .0 8,13 ]-hexadecane cage-like skeleton. Aspersorbiciols A and B suppressed lipopolysaccharide-induced NF-κB luciferase activities and the receptor activator of NF-κB ligand-induced osteoclastogenesis.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Marine Sponges and Natural Products Carbohydrate Chemistry and Synthesis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
4
Pages
1175–1180
Publication date
21 January 2026
Language
EN