Photodriven Fluoroalkylation–Alkoxylation of Enol Ethers via Electron Donor–Acceptor Complex of Bromodifluoroacetamides

Organic Letters 2026

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Authors: Weijie Si, Zhanghong Wang, Hongyi Yang, Wen-Chao Yang
DOI: 10.1021/acs.orglett.5c04796
Cited by: 18
References: 52

Abstract

We herein describe an unprecedented photoinduced EDA-enabled multicomponent reaction for the construction of fluorinated acetals from enol ethers, bromodifluoroacetamides, and alcohols, which enables late-stage functionalization of acetals. This reaction involved a cascade XAT/radical addition/SET/alkoxylation process. The reaction exhibited a broad substrate scope and a wide functional group compatibility.

Fields of Study & Subjects

Fluorine in Organic Chemistry Radical Photochemical Reactions Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
3
Pages
942–947
Publication date
8 January 2026
Language
EN