Synthesis of Dibenzo[ a , e ]cyclooctatetraenes Enabled by a Palladium-Catalyzed Cross-Coupling Reaction
Abstract
Herein, we report a palladium-catalyzed cross-coupling reaction of sulfonylhydrazones with aryl or alkenyl halides, affording a diverse array of substituted dibenzo[ a, e ]cyclooctatetraenes featuring planar chirality. Substituents can be efficiently installed onto both aryl and alkene moieties. Preliminary asymmetric investigations have also been conducted, presenting a promising strategy for the enantioselective synthesis of cyclooctatetraene, an underexplored chiral diene ligand.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Cyclopropane Reaction Mechanisms
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 2
- Pages
- 686–690
- Publication date
- 5 January 2026
- Language
- EN