Cross-Dehydrogenative Coupling of Ligated Boranes with Aldehydes for the Direct Synthesis of Acylboranes

Organic Letters 2026

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Authors: Ji-Nan Sun, Chunru Wang, Xuan‐Hui Ouyang, Ming Hu, Chao Hu, Jin‐Heng Li
DOI: 10.1021/acs.orglett.5c04807
Cited by: 0
References: 51

Abstract

Acylboranes are valuable building blocks in synthesis and bioconjugation, yet their preparation remains challenging. We report the first transition-metal-free cross-dehydrogenative coupling of aldehydes with ligated boranes, providing direct access to acylboranes under mild oxidative conditions. The reaction exhibits a broad substrate scope and functional group tolerance, and mechanistic studies support a radical pathway. The resulting acylboranes undergo diverse downstream transformations, including Suzuki coupling, homologation, and amination, highlighting the versatility and synthetic utility of this approach.

Fields of Study & Subjects

Organoboron and organosilicon chemistry Catalytic Cross-Coupling Reactions Radical Photochemical Reactions

Publication details

Journal / source
Organic Letters
Volume
28
Issue
4
Pages
1181–1185
Publication date
19 January 2026
Language
EN