Direct β-C(sp 3 )–H Functionalization to Carbonyls: A Route to Aldehydic Acid Derivatives

Organic Letters 2026

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Authors: Koneti Kondalarao, Matteda Priyanka, Akhila K. Sahoo
DOI: 10.1021/acs.orglett.5c04857
Cited by: 2
References: 51

Abstract

We describe a general strategy for C═O bond formation through palladium-catalyzed β-C(sp 3 )–H functionalization using sulfoximine as a neutral directing group. This method enables chemoselective oxidation of inert β-C(sp 3 )–H bonds to aldehydes with 2-nitro-iodylbenzene as an exclusive oxidant and oxygen source. The cooperative effect of the directing group and ligand ensures high selectivity. This strategy exhibits broad functional group tolerance and can be used to advance complex molecule development.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Synthesis and Catalytic Reactions Oxidative Organic Chemistry Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
9
Pages
2825–2830
Publication date
23 February 2026
Language
EN