Electrochemical Activation of α-Carbonyl Alkoxyamines for Direct Nucleophilic Substitution
Abstract
High Resolution Image Download MS PowerPoint Slide The reactivity and synthetic utility of TEMPO-derived alkoxyamines as functional handles remains insufficiently explored. This report interrogates the factors governing the stereospecific substitution of electroactivated TEMPO-derived α-carbonyl alkoxyamines. Concurrent with direct electrolysis, electroanalytical studies and theoretical calculations provided a complementary platform by which one could predict the efficacy for substrates to undergo desired substitution using benzoic acid or N -sulfonyl carbamate nucleophiles.
Fields of Study & Subjects
Radical Photochemical Reactions
Oxidative Organic Chemistry Reactions
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 6
- Pages
- 1941–1946
- Publication date
- 3 February 2026
- Language
- EN