Hydrogenation of Fluoroalkyl Ketones on Water under Atmospheric Pressure Catalyzed by a Water-Soluble Metal–Ligand Bifunctional Iridium Catalyst
Abstract
The hydrogenation of fluoroalkyl ketones on water under atmospheric pressure has been accomplished. In the presence of water-soluble iridium complex [Cp*Ir(6,6′-(OH) 2 -2,2′-bpy)(OH 2 )][OTf] 2 (0.5 mol %), a series of desirable products were obtained in high yields. It was confirmed that OH functional groups in bpy ligand are crucially important for the catalytic activity. Furthermore, DFT calculations and the application potential of the present catalytic system are also presented.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 3
- Pages
- 948–953
- Publication date
- 8 January 2026
- Language
- EN