Minisci-Type C–H Methylation and Silylation of Heteroarenes with Visible Light and N -Fluorobenzenesulfonimide

Organic Letters 2026

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Authors: Cheng Huang, Chen-Lu Wang, Hao-Ran Liu, Chen Kang, Sheng Tang, Zhong-Ming Ye, Chang-Ming You, Jia Qiao, Zhenhong Wei, Hu Cai
DOI: 10.1021/acs.orglett.5c04922
Cited by: 2
References: 51

Abstract

Herein, we report a photochemical C–H methylation and silylation of heteroarenes through the combination of visible light and N -fluorobenzenesulfonimide (NFSI). This practical method allows for the incorporation of a methyl or silyl group, produced from methanol and hydrosilane, into heteroarene architectures in a photocatalyst- and metal-free fashion. Mechanistic investigation suggests that the N-centered radical, generated from homolysis of the N–F bond in NFSI, plays a critical role by abstracting a hydrogen atom from a C–H or Si–H bond.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Organoboron and organosilicon chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
2
Pages
740–745
Publication date
6 January 2026
Language
EN